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Cancer procoagulant

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Cancer procoagulant
Identifiers
EC no.3.4.22.26
CAS no.109456-80-6
Databases
IntEnzIntEnz view
BRENDABRENDA entry
ExPASyNiceZyme view
KEGGKEGG entry
MetaCycmetabolic pathway
PRIAMprofile
PDB structuresRCSB PDB PDBe PDBsum
Search
PMCarticles
PubMedarticles
NCBIproteins

Cancer procoagulant is a hypothesised protein, most likely a cysteine protease enzyme (EC 3.4.22.26), that occurs only in fetal and malignant cells. Its activity appears to be the activation of factor X, one of the coagulation factors, and would account for the increased incidence of thrombosis in cancer patients. Tissue factor (TF) is also known to be present at increased levels around malignant cells.

References

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  • De Cicco M (June 2004). "The prothrombotic state in cancer: pathogenic mechanisms". Critical Reviews in Oncology/Hematology. 50 (3): 187–96. doi:10.1016/j.critrevonc.2003.10.003. PMID 15182825.
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